We’re in the midst of an epidemic of chronic disease unlike anything human beings have ever experienced. It has eroded our quality of life, threatened the health of future generations, and consumed trillions of dollars of year of vital economic resources. Unfortunately, our current healthcare (i.e. disease management) system has not only failed to address the problem, it has contributed to it. In this presentation, I will discuss two relatively new concepts in medicine: the exposome and epigenetics, and show how they will form the basis of a more integrative, preventative, and functional model of healthcare with the potential to reverse the current disease epidemic and radically improve our health.