The World Health Organization believes that depression may become the biggest health burden in the world within just a few years (by their estimations, 2020). In the United States, depression affects literally a quarter of the population. But what is depression? Is it really just a serotonin deficiency? Or some sort of Prozac deficiency? Current research has actually been steering us away from the neurotransmitter model of depression for quite some time now, even as the outdated pharmacologic SSRI interventions treating it like a serotonin deficiency continue to persist. We will discuss the true foundational origins of depression and what is truly needed to overcome it.